Lack of Association between Glutathione Peroxidase 1 (pro197leu) Polymorphism and Cchizophrenia in a Turkish Population Şizofreni ve Glutatyon Peroksidaz 1 (pro197leu) Polimorfizmi Arasındaki İlişkinin bir Türk Hasta Grubunda Araştırılması

Introduction: Schizophrenia is a complex disease characterized with psychosis, cognitive dysfunction and negative symptoms. The etiology is unknown in most cases. Free radicals and antioxidant system balance shifting in favor of oxidants resulted from oxidative stress has been accounted for in the pathogenesis of schizophrenia. In this study, we aimed to elucidate the role of the pro197leu polymorphism of glutathione peroxidase 1 (GPX1) enzyme, the major subunit of glutathione peroxidase, in the etiopathogenesis of schizophrenia. Materials and Methods: The study group was composed of 100 patients (54 males and 46 females) and 100 healthy volunteers (66 males and 34 females). The study was conducted using the PCR\RFLP method. Results: The allele frequencies of pro197 and leu197 variants of GPX1 were similar in the control group and schizophrenic patients (p=0.318). Distributions of the genotype frequencies were similar between the controls and patients (p=0.402), as well as males and females in patient group (p=0.225). Conclusion: The pro197leu polymorphism of GPX1 gene may not constitute any susceptibility for schizophrenia in Turkish population studied.